[HTML][HTML] Phytochemicals in cancer treatment: From preclinical studies to clinical practice

AS Choudhari, PC Mandave, M Deshpande… - Frontiers in …, 2020 - frontiersin.org
Cancer is a severe health problem that continues to be a leading cause of death worldwide.
Increasing knowledge of the molecular mechanisms underlying cancer progression has led …

[HTML][HTML] Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

YK Mahmoud, HMA Abdelrazek - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …

[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

[HTML][HTML] MicroRNA and ROS crosstalk in cardiac and pulmonary diseases

M Climent, G Viggiani, YW Chen, G Coulis… - International Journal of …, 2020 - mdpi.com
Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

The neuroprotective effects of thymoquinone: a review

T Farkhondeh, S Samarghandian… - Dose …, 2018 - journals.sagepub.com
Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very
useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic …

Thymoquinone‐induced antitumor and apoptosis in human lung adenocarcinoma cells

S Samarghandian, M Azimi‐Nezhad… - Journal of cellular …, 2019 - Wiley Online Library
Background Lung cancer has been associated with the highest cancer‐associated mortality
rate in the world. Chemotherapeutic management of cancer necessitates introducing new …

Recent advances in herbal combination nanomedicine for cancer: delivery technology and therapeutic outcomes

DM Anwar, M El-Sayed, A Reda, JY Fang… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: The use of herbal compounds in cancer therapy has great potential to promote
the efficacy of current cancer therapeutic strategies. Herbal compounds were successfully …

[HTML][HTML] Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics

MA Khan, M Tania, J Fu - Drug discovery today, 2019 - Elsevier
Highlights•Thymoquinone is a natural product with anticancer activity.•Thymoquinone can
methylate or demethylate DNA.•Thymoquinone can interfere with the histone acetylation …

Formulation, cellular uptake and cytotoxicity of thymoquinone-loaded PLGA nanoparticles in malignant melanoma cancer cells

WN Ibrahim, L Muizzuddin Bin Mohd Rosli… - International journal …, 2020 - Taylor & Francis
Introduction Thymoquinone (TQ) is the main active compound extracted from Nigella sativa
a traditional herb with wide therapeutic applications and recognizable anticancer properties …

[HTML][HTML] Insight into the biological roles and mechanisms of phytochemicals in different types of cancer: targeting cancer therapeutics

TA Majrashi, SA Alshehri, A Alsayari, AB Muhsinah… - Nutrients, 2023 - mdpi.com
Cancer is a hard-to-treat disease with a high reoccurrence rate that affects health and lives
globally. The condition has a high occurrence rate and is the second leading cause of …