Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its
detachment from microtubules and formation of insoluble intracellular aggregates within the …

Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …

Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been
thought to be the biologically active, toxic form of tau mediating neurodegeneration in …

Abstract Positron Emission Tomography (PET) ligands have advanced Alzheimer's disease
(AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identify AD brain …

Paired helical filaments (PHFs) from the Alzheimer's disease (AD) brain are highly
ubiquitinated and ubiquitination likely plays a vital role in tau filament formation. Whether tau …

The two hallmarks of Alzheimer's disease (AD) are amyloid‐β (Aβ) plaques and
neurofibrillary tangles marked by phosphorylated tau. Increasing evidence suggests that …

Alpha-synuclein (aSyn) pathology is present in approximately 50% of Alzheimer's disease
(AD) cases at autopsy and might impact the age-of-onset and disease progression in AD …

The microtubule associated protein, tau, is implicated in a multitude of neurodegenerative
disorders that are collectively termed as tauopathies. These disorders are characterized by …

Alzheimer's disease (AD) is the most common form of dementia, and ginsenoside Rg2 (Rg2)
is proven to inhibit AD's progression. This study investigates the potential benefits of Rg2 …

Recent findings of diverse populations of prion-like conformers of misfolded tau protein
expand the prion concept to Alzheimer's disease (AD) and monogenic frontotemporal lobar …