Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex
HV Heemers, DJ Tindall - Endocrine reviews, 2007 - academic.oup.com
Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …
of the male phenotype during embryogenesis, the achievement of sexual maturation at …
Genomic and biochemical insights into the specificity of ETS transcription factors
PC Hollenhorst, LP McIntosh… - Annual review of …, 2011 - annualreviews.org
ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …
These proteins direct gene expression in diverse normal and disease states by binding to …
Benchmark and integration of resources for the estimation of human transcription factor activities
The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the
oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but …
oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but …
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
The androgen receptor (AR) is a key regulator of prostate growth and the principal drug
target for the treatment of prostate cancer. Previous studies have mapped AR targets and …
target for the treatment of prostate cancer. Previous studies have mapped AR targets and …
The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man
NL Sharma, CE Massie, A Ramos-Montoya, V Zecchini… - Cancer cell, 2013 - cell.com
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is
the commonest cancer in men in the UK. We present a comprehensive analysis of AR …
the commonest cancer in men in the UK. We present a comprehensive analysis of AR …
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence
The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in
cell-cycle control. However, cancer-associated mutations are almost exclusively found in …
cell-cycle control. However, cancer-associated mutations are almost exclusively found in …
ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors
S Oh, S Shin, R Janknecht - Biochimica et Biophysica Acta (BBA)-Reviews …, 2012 - Elsevier
The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS
transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 …
transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 …
The role of the transcription factor Ets1 in carcinoma
J Dittmer - Seminars in cancer biology, 2015 - Elsevier
Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …
Genetic and molecular insights into the development and evolution of sexual dimorphism
TM Williams, SB Carroll - Nature Reviews Genetics, 2009 - nature.com
Sexual dimorphism is common throughout the animal kingdom. However, a molecular
understanding of how sex-specific traits develop and evolve has been elusive. Recently …
understanding of how sex-specific traits develop and evolve has been elusive. Recently …