A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …

Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …

Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date
and are ideally positioned to take advantage of our increasing understanding of …

The hepatitis C virus (HCV) has developed a small membrane protein, p7, which remarkably
can self-assemble into a large channel complex that selectively conducts cations,,,. We …

Since the severe acute respiratory syndrome (SARS) outbreak in 2003, human
coronaviruses (hCoVs) have been identified as causative agents of severe acute respiratory …

The hepatitis C virus (HCV) p7 protein is critical for virus production and an attractive
antiviral target. p7 is an ion channel when reconstituted in artificial lipid bilayers, but channel …

Non-structural protein 2 (NS2) plays an important role in hepatitis C virus (HCV) assembly,
but neither the exact contribution of this protein to the assembly process nor its complete …

The channel-forming activity of a family of small, hydrophobic integral membrane proteins
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …

Hepatitis C infection is the leading cause of liver diseases worldwide and a major health
concern that affects an estimated 3% of the global population. Novel therapies available …