Pre-existing cross-reactive immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …

The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …

Background The function of the thymus in human adults is unclear, and routine removal of
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …

For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and
inflammation is a centrally important hallmark,,,,,–. Here we examined whether IL-11, a pro …

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …

The microbiome plays a fundamental role in the maturation, function, and regulation of the
host-immune system from birth to old age. In return, the immune system has co-evolved a …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Método: Se examinaron las publicaciones más relevantes en relación con los objetivos de
la revisión. Resultados: La enfermedad, conocida como COVID-19, cursa con tos, fiebre y …