The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of
investigators with a wide range of research interests, but all attempting to correlate drug …

The ultrarapid delayed rectifier channels have attracted considerable interest as targets for
'atrial-selective'antiarrhythmic drugs because they contribute to atrial but not to ventricular …

Atrial fibrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac
atria. Predisposing to stroke and heart failure, this common condition is increasingly …

Aims Genetic factors may be important in the development of atrial fibrillation (AF) in the
young. KCNA5 encodes the potassium channel α-subunit KV1. 5, which underlies the …

The pore-forming α-subunit, Kv1. 5, forms functional voltage-gated K+ (Kv) channels in
human pulmonary artery smooth muscle cells (PASMC) and plays an important role in …

Atrial fibrillation (AF) is the most common cardiac rhythm abnormality and represents a major
burden, both to patients and to health-care systems. In recent years, increasing evidence …

Objectives: The aim of this study was to evaluate the role of cardiac K+ channel gene
variants in families with atrial fibrillation (AF). Background: The K+ channels play a major …

Background: Pharmacogenetics uses genetic variation to predict individual differences in
response to medications and holds much promise to improve treatment of addictive …

Atrial fibrillation (AF) is the most common sustained arrhythmia. Anti-arrhythmic drugs
remain the mainstay of therapy, but the available class I and III anti-arrhythmic drugs are …

Aims: Psychiatric pharmacogenetics involves the use of genetic tests that can predict the
effectiveness of treatments for individual patients with mental illness such as drug …