The primary developing trends in flexible and stretchable electronics involve the innovation
of material synthesis, mechanical design, and fabrication strategies that employ soft …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …

In this article, we discuss the recent progress on controlled structural modification of 2D
materials by means of molecular functionalization, with a focus on scanning probe …

Recent structural characterizations of classical and non‐classical major histocompatibility
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Peptide binding to major histocompatibility complex class II (MHCII) molecules is a key
process in antigen presentation and CD4+ T cell epitope selection. This unit describes a …

Ag presentation by MHC class II (MHC II) molecules to CD4+ T cells plays a key role in the
regulation of the adaptive immune response. Loading of antigenic peptides onto MHC II is …

T cell antigen receptors (TCRs) expressed on cytotoxic or helper T cells can only see their
specific target antigen as short sequences of peptides bound to the groove of proteins of …

Peptides bind MHC class II molecules through a thermodynamically nonadditive process
consequent to the flexibility of the reactants. Currently, how the specific outcome of this …