Background To assess the worldwide variation of amyotrophic lateral sclerosis (ALS)
incidence, we performed a systematic review and meta-analysis of population-based data …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Although amyotrophic lateral sclerosis (ALS) is relatively rare, the socioeconomic
significance of the disease is extensive. It is therefore vital to project the epidemiologic trend …

Background Understanding how prevalence, incidence, and mortality of motor neuron
diseases change over time and by location is crucial for understanding the causes of these …

Superoxide dismutase (SOD1) gene variants may cause amyotrophic lateral sclerosis, some
of which are associated with a distinct phenotype. Most studies assess limited variants or …

Amyotrophic lateral sclerosis (ALS) epidemiology has rapidly developed in the last 30 years
alongside the evolving changes in concepts in the field of clinical ALS and also due to the …

Abstract Neurodegenerative diseases (NDs), including Alzheimer's disease (AD),
Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), exhibit high phenotypic …

Prospective population based-registers of amyotrophic lateral sclerosis (ALS) have operated
in Europe for over two decades, and have provided important insights into our …

Up-to-date, accurate information on the disease burden of motor neuron disease (MND) is
the cornerstone for evidence-based resource allocation and healthcare planning. We aimed …