The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …

In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …

Abnormal accumulation of aggregated α-synuclein (aSyn) is a hallmark of sporadic and
familial Parkinson's disease (PD) and related synucleinopathies. Recent studies suggest a …

Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism
including different actions in the brain. PRL exerts a neuroprotective effect against …

Refractoriness to existing medications of up to 80% of the patients with mesial temporal lobe
epilepsy (MTLE) prompts for finding new antiepileptic drug targets. The adenosine A 2A …

Caffeine is associated with procognitive effects in humans by counteracting overactivation of
the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged …

Adenosine A2A receptor (A2AR) antagonists are the leading nondopaminergic therapy to
manage Parkinson's disease (PD) since they afford both motor benefits and neuroprotection …

There is a growing consensus that Alzheimer's disease (AD) involves failure of the
homeostatic machinery, which underlies the firing stability of neural circuits. What are the …