The liver has the unique capacity to regenerate in response to a damaging event. Liver
regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell …

PDL1 blockade produces remarkable clinical responses, thought to occur by T cell
reactivation through prevention of PDL1-PD1 T cell inhibitory interactions. Here, we find that …

T cell receptor (TCR) down‐modulation after antigen presentation is a fundamental process
that regulates TCR signal transduction. Current understanding of this process is that intrinsic …

Viral vectors are promising gene carriers for cancer therapy. However, virus-mediated gene
therapies have demonstrated insufficient therapeutic efficacy in clinical trials due to rapid …

Many cancer patients do not benefit from PD-L1/PD-1 blockade immunotherapies. PD-1 and
LAG-3 co-upregulation in T-cells is one of the major mechanisms of resistance by …

The ubiquitous shortage of primary human hepatocytes has urged the scientific community
to search for alternative cell sources, such as immortalized hepatic cell lines. Over the years …

Myeloid-derived suppressor cells (MDSCs) differentiate from bone marrow precursors,
expand in cancer-bearing hosts and accelerate tumor progression. MDSCs have become …

Efficacious antitumor vaccines strongly stimulate cancer-specific effector T cells and
counteract the activity of tumor-infiltrating immunosuppressive cells. We hypothesised that …

Sulfated progesterone metabolite (P4-S) levels are raised in normal pregnancy and
elevated further in intrahepatic cholestasis of pregnancy (ICP), a bile acid-liver disorder of …

Objective Most therapeutic treatments for autoimmune arthritis rely on immunosuppressive
drugs, which have side effects. Although a previous study by our group showed that specific …