RNA has diverse cellular functionality, including regulating gene expression, protein
translation, and cellular response to stimuli, due to its intricate structures. Over the past …

With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

Recruiting the endogenous editing enzyme adenosine deaminase acting on RNA (ADAR)
with tailored guide RNAs for adenosine-to-inosine (A-to-I) RNA base editing is promising for …

Adenosine deaminases acting on RNA (ADARs) are endogenous enzymes catalyzing the
deamination of adenosines to inosines, which are then read as guanosines during …

AIMers are short, chemically modified oligonucleotides that induce A-to-I RNA editing
through interaction with endogenous adenosine deaminases acting on RNA (ADAR) …

The tree shrew (Tupaia belangeri) has long been proposed as a suitable alternative to non-
human primates (NHPs) in biomedical and laboratory research due to its close evolutionary …

Phase separation is a critical mechanism for partitioning cellular functions by specific
aggregation of biological macromolecules. Recent studies have found that phase separation …

Epitranscriptomics is a field that delves into post-transcriptional changes. Among these
modifications, the conversion of adenosine to inosine, traduced as guanosine (A> I (G)), is …

Inosine (I), resulting from the deamination of adenosine (A), is a prominent modification in
the human transcriptome. The enzymes responsible for the conversion of adenosine to …

In this article, I recount my memories of key experiments that led to my entry into the RNA
editing/modification field. I highlight initial observations made by the pioneers in the ADAR …