At present, antibiotic resistance represents a global problem in modern medicine. In the near
future, humanity may face a situation where medicine will be powerless against resistant …

As mitochondria are negatively charged organelles, penetrating cations are used as parts of
chimeric molecules to deliver specific compounds into mitochondria. In other words, they are …

Microbial infections and antibiotic resistance are some of the prime factors that are ascribed
to endanger human health. Several reports have highlighted that drug-resistant pathogens …

A previously developed model to predict antibacterial activity of ionic liquids against a
resistant A. baumannii strain was used to assess activity of phosphonium ionic liquids. Their …

Lam proteins transport sterols between the membranes of different cellular compartments. In
Saccharomyces cerevisiae, the LAM gene family consists of three pairs of paralogs …

Microbial cells sense the presence of xenobiotics and, in response, upregulate genes
involved in pleiotropic drug resistance (PDR). In yeast, PDR activation to a major extent …

Aims FcεRI-dependent activation and degranulation of mast cells (MC) play an important
role in allergic diseases. We have previously demonstrated that triphenylphosphonium …

Eukaryotic cells rely on multiple mechanisms to protect themselves from exogenous toxic
compounds. For instance, cells can limit penetration of toxic molecules through the plasma …

Pleiotropic drug resistance (PDR) plasma membrane transporters mediate xenobiotic efflux
from the cells and thereby help pathogenic microorganisms to withstand antimicrobial …

SkQ1, a novel antibiotic targeting bacterial bioenergetics, is highly effective against both
gram-positive and gram-negative bacteria. However, some gram-negative bacteria, such as …