The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts …

The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by
actively proliferating Lgr5+ stem cells. Bone morphogenetic protein (BMP) signalling …

Exposure of articular cartilage to excessive mechanical loading is deeply involved in the
pathogenesis of osteoarthritis. Here, we identify gremlin-1 as a mechanical loading …

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated
proteins that regulate a wide range of developmental processes, including limb and kidney …

Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key
aspects of their biology remain poorly elucidated. Here, comparative transcriptomic analyses …

While the neuronal underpinnings of autism spectrum disorder (ASD) are being unraveled,
vascular contributions to ASD remain elusive. Here, we investigated postnatal …

Abstract Background Bone morphogenetic proteins (BMPs) have been reported to maintain
epithelial integrity and to antagonize the transforming growth factor β (TGFβ)-induced …