Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …

Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

▪ Abstract The p21-activated kinases (PAKs) 1–3 are serine/threonine protein kinases whose
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …

Abstract PAKs, p21-activated kinases, play central roles and act as converging junctions for
discrete signals elicited on the cell surface and for a number of intracellular signaling …

Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma
leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical …

The receptor tyrosine kinase Tie2, and its activating ligand Angiopoietin-1 (Ang1), are
required for vascular remodelling and vessel integrity, whereas Ang2 may counteract these …

The protein-tyrosine phosphatase Shp2 plays an essential role in growth factor and integrin
signaling, and Shp2 mutations cause developmental defects and/or malignancy. Previous …

Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for
Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a …

Endothelial cells receive multiple information from their environment that eventually leads
them to progress along all the stages of the process of formation of new vessels. Angiogenic …

Angiopoietins are ligands of the Tie2 receptor that control angiogenic remodeling in a
context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic …