The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Studying posttranslational modifications classically relies on experimental strategies that
oversimplify the complex biosynthetic machineries of living cells. Protein glycosylation …

Highlights•Approaches for glycoproteomics are rapidly diversifying expanding the classes of
glycosylation able to be studied en masse.•N-linked, Mucin-O-linked and O-GlcNAc …

Facilitated by advances in the separation sciences, mass spectrometry and informatics,
glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling …

Post-translational modifications (PTMs) are a fundamental phenomenon across all classes
of life and several hundred different types have been identified. PTMs contribute widely to …

Post‐translational modifications (PTMs) greatly expand the function and potential for
regulation of protein activity, and O‐glycosylation is among the most abundant and diverse …

Mucin-type GalNAc O-glycosylation is one of the most abundant and unique post-
translational modifications. The combination of proteome-wide mapping of GalNAc O …

Consisting of a defined set of extracellular proteins secreted from resident cells and with
minor contributions from serum proteins, the extracellular matrix (ECM) is an essential …