The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction
pathways involved in cell division, motility, adhesion, and survival in both normal and cancer …

Breast cancers that are negative for estrogen receptor (ER), progesterone receptors (PR)
and HER2, using standard clinical assays, have been dubbed triple‐negative (TN). Unlike …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy and
new therapeutics are much needed. Profiling patient leukemia drug sensitivities ex vivo, we …

Purpose Src family kinases (SFKs) promote cancer progression and are commonly
expressed in non–small-cell lung cancer (NSCLC), but the clinical effects of SFK inhibition in …

Two novel prodrug polymers POEG-b-PSSDas (redox-sensitive) and POEG-b-PCCDas
(redox-insensitive), which consist of poly (oligo (ethylene glycol) methacrylate)(POEG) …

Background Triple-negative breast cancers lack expression of estrogen and progesterone
receptors and overexpression of human epidermal growth factor receptor 2 (HER2). Unlike …

Carrier-free drug self-delivery systems consisting of amphiphilic drug-drug conjugate
(ADDC) with well-defined structure and nanoscale features have drawn much attention in …

Dasatinib (DAS) is a multikinase inhibitor that acts on several signaling kinases. DAS is
used as a second-line treatment for chronic accelerated myeloid and Philadelphia …

In this work, a novel highly sensitive electrochemical sensing platform has been developed
for simultaneous determination of anticancer drugs doxorubicin (DOX) and dasatinib (DAS) …

Dasatinib (BMS-354825, Sprycel®) is an oral, multitargeted inhibitor of receptor tyrosine
kinases (RTKs), including BCR-ABL fusion protein, stem cell factor receptor (c-KIT), platelet …