Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …

Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy,
it plays important roles in embryo development, implantation, placental development and …

BACKGROUND Obesity among pregnant women is highly prevalent worldwide and is
associated in a linear manner with markedly increased risk of adverse outcome for mother …

Maternal lipids are strong determinants of fetal fat mass. Here we review the overall lipid
metabolism in normal and gestational diabetes mellitus (GDM) pregnancies. During early …

Most obese individuals have elevated plasma levels of free fatty acids (FFA) which are
known to cause peripheral (muscle) insulin resistance. They do this by inhibiting insulin …

Ubiquitination and deubiquitination are reversible processes that modify the characteristics
of target proteins, including stability, intracellular localization, and enzymatic activity …

Evidence is presented that shows that free fatty acids (FFA) are one important link between
obesity, insulin resistance, and type 2 diabetes. Plasma FFA levels are elevated in most …

Objective Long-chain omega 3 fatty acids, eicosapentaenoic acid (EPA, 20: 5n-3) and
docosahexaenoic acid (DHA, 22: 6n-3) exert potent anti-inflammatory properties in humans …

Elevated plasma FFA levels have been shown to account for up to 50% of insulin resistance
in obese patients with type 2 diabetes mellitus. Lowering of FFAs in these patients or …

Gestational diabetes mellitus is a hyperglycaemic state first recognised in pregnancy. GDM
affects both mother and child. Women with GDM and their new-borns are at risk of …