The use of covalent chemistry to track biomolecules in their native environment—a focus of
bioorthogonal chemistry—has received considerable interest recently among chemical …

Bioorthogonal chemical reactions have emerged as convenient and rapid methods for
incorporating unnatural functionality into living systems. Different prototype reactions have …

Click chemistry has been established rapidly as one of the most valuable methods for the
chemical transformation of complex molecules. Due to the rapid rates, clean conversions to …

The incorporation of aldehyde handles into proteins, and subsequent chemical reactions
thereof, is rapidly proving to be an effective way of generating homogeneous, covalently …

Highlights•Strain-promoted alkyne-nitrone cycloadditions (SPANCs) are rapid and efficient
bioorthogonal reactions.•Endocyclic nitrones are water stable and preferred substrates for …

Due to their rapid and highly selective nature, bioorthogonal chemistry reactions are
attracting a significant amount of recent interest in the radiopharmaceutical community. Over …

The ability to achieve predictable control over the polarization of strained cycloalkynes can
influence their behavior in subsequent reactions, providing opportunities to increase both …

Mitochondria are critical regulators of cellular function and survival. Delivery of therapeutic
and diagnostic agents into mitochondria is a challenging task in modern pharmacology …

Nitrone chemistry has been widely developed for a long time and many reviews have
outlined its rich transformation chemistry. However, most of these reviews involve …

The use of bioorthogonal probes that display fluorogenic or phosphorogenic properties is
advantageous to the labeling and imaging of biomolecules in live cells and organisms …