Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various
hormones and extracellular matrix components. FAP is highly upregulated in a wide variety …

Abstract CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death
receptor/death ligand system that mediates apoptosis induction to maintain immune …

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

Autophagy regulates cell death both positively and negatively, but the molecular basis for
this paradox remains inadequately characterized. We demonstrate here that transient cell-to …

Metastatic cancer cells can develop anoikis resistance in the absence of substrate
attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria …

Genome-wide DNA methylation patterns are established and maintained by the coordinated
action of three DNA methyltransferases (DNMTs), DNMT1, DNMT3A and DNMT3B …

The fate of a cell is determined by multiple signaling pathways in response to a range of
stimuli. Probably the most prominent cell death mechanism is apoptosis which can be …

Allosteric communication is a fundamental process that proteins use to propagate signals
from one site to functionally important distal sites. Although allostery is usually associated …

Introduction: The Fas/FasL system plays a significant role in tumorigenesis. Research has
shown that its impairment in cancer cells may lead to apoptosis resistance and contribute to …