Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disease, develops and progresses for 10–15 years before the clinical …

Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies.
However, it is not known what controls the formation and templated seeding of strain-specific …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's
Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation …

Several aggregation-prone proteins associated with neurodegenerative diseases can be
modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α …