Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning

P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Design principles for therapeutic angiogenic materials

PS Briquez, LE Clegg, MM Martino… - Nature Reviews …, 2016 - nature.com
Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …

[HTML][HTML] Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer

C Kut, F Mac Gabhann, AS Popel - British journal of cancer, 2007 - nature.com
Vascular endothelial growth factor (VEGF) is a major target for the inhibition of tumour
vascularisation and the treatment of human cancer. Many tumours produce large quantities …

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use

FTH Wu, MO Stefanini, FM Gabhann… - Journal of cellular …, 2010 - Wiley Online Library
Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …

Angiogenesis-regulating microRNAs and ischemic stroke

KJ Yin, M Hamblin… - Current vascular …, 2015 - ingentaconnect.com
Stroke is a leading cause of death and disability worldwide. Ischemic stroke is the dominant
subtype of stroke and results from focal cerebral ischemia due to occlusion of major cerebral …

Systems biology of vascular endothelial growth factors

FM Gabhann, AS Popel - Microcirculation, 2008 - Taylor & Francis
Several cytokine families have roles in the development, maintenance, and remodeling of
the microcirculation. Of these, the vascular endothelial growth factor (VEGF) family is one of …

Multiscale models of angiogenesis

AA Qutub, F Mac Gabhann… - IEEE engineering in …, 2009 - ieeexplore.ieee.org
This article aims to promote integration of angiogenesis-related models, both integration of
the work described herein and many other existing and future models. Integration of …

[HTML][HTML] A compartment model of VEGF distribution in blood, healthy and diseased tissues

MO Stefanini, FTH Wu, F Mac Gabhann, AS Popel - BMC systems biology, 2008 - Springer
Background Angiogenesis is a process by which new capillaries are formed from pre-
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …

[HTML][HTML] A hybrid model for three-dimensional simulations of sprouting angiogenesis

F Milde, M Bergdorf, P Koumoutsakos - Biophysical journal, 2008 - cell.com
Recent advances in cancer research have identified critical angiogenic signaling pathways
and the influence of the extracellular matrix on endothelial cell migration. These findings …

No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men

TP Gavin, RS Ruster, JA Carrithers… - The Journal of …, 2007 - Wiley Online Library
Ischaemia‐induced skeletal muscle angiogenesis is impaired in aged compared with young
mice. In humans, vascular endothelial growth factor (VEGF) mRNA and protein following an …