Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH)
releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the
release of GH. It is a first hormone linking gastrointestinal-pituitary axis. Objective: This …

Diabetes mellitus, a disease that affects nearly 536.6 million people worldwide, is
characterized by the death or dysfunction of insulin-producing beta cells of the pancreas …

Ghrelin plays an important physiological role in modulating GH secretion, insulin secretion
and glucose metabolism. Ghrelin has direct effects on pancreatic islet function. Also, ghrelin …

Background There is increasing evidence that unacylated ghrelin (UAG) improves insulin
sensitivity and glucose homeostasis; however, the mechanism for this activity is not fully …

The metabolic actions of the ghrelin gene‐derived peptide obestatin are still unclear. We
investigated obestatin effects in vitro, on adipocyte function, and in vivo, on insulin …

Ghrelin, a 28 amino acid peptide hormone produced by the stomach, was the first orexigenic
hormone to be discovered from the periphery. The octanoyl modification at Ser 3, mediated …

Along with the increase in life expectancy over the last century comes the increased risk for
development of age-related disorders, including metabolic and neurodegenerative diseases …