Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Fibrotic diseases are a significant global burden for which there are limited treatment
options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly …

Transforming growth factor-β (TGF-β) is a common mediator of cancer progression and
fibrosis. Fibrosis can be a significant pathology in multiple organs, including the heart. In this …

Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an
excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead …

The present study investigated the effect of hesperidin, a natural flavonoid, in cardiac
ischemia and reperfusion (I/R) injury in diabetic rats. Male Wistar rats with diabetes were …

Coronary artery disease remains a major cause of morbidity and mortality. Experimental and
clinical data have indicated an important role of endothelin-1 at various subclinical and …

It has been documented that Ca 2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes …

Exposure to air pollution negatively impacts cardiovascular health. Studies show that
increased exposure to a number of airborne pollutants increases the risk for cardiovascular …

Endothelin-1 (ET-1) has been implicated in the pathogenesis of cardiac fibrosis. Stimulation
of endothelin receptors (ETR) with ET-1 leads to fibroblast activation and myofibroblast …