Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …

Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew,
predisposes DNA sequences toward R-loop formation upon transcription. Previous work …

Previous observations have demonstrated that embryonic exposure to the endocrine
disruptor vinclozolin during gonadal sex determination promotes transgenerational adult …

Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are
associated with a broad range of disease traits, including cancer, asthma, metabolic …

The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …

DNA methylation plays a crucial role in the regulation of gene expression and chromatin
organization within normal eukaryotic cells. In cancer, however, global patterns of DNA …

Although epidemiological studies support the role of environment in a wide range of human
cancers, the precise mechanisms by which environmental exposures promote cancer …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

Epigenetic variation may significantly contribute to the risk of common disease. Currently,
little is known about the extent and causes of epigenetic variation. Here, we investigated the …