This review provides a selected overview of some of the significant developments that have
occurred in ion chromatography (IC) over recent years, together with some views on the …

Summary Background This phase I/II study determined the maximal tolerable dose, dose
limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics of …

Endogenous ribonucleotides and deoxyribonucleotides play a crucial role in cell function.
The determination of their levels is of fundamental interest in numerous applications such as …

We examined the analysis of nucleotides and nucleotide sugars by chromatography on
porous graphitic carbon with mass spectrometric detection, a method that evades …

Background Gemcitabine is used to treat a wide range of tumours, but its efficacy is limited
by cancer cell resistance mechanisms. NUC-1031, a phosphoramidate modification of …

Purpose Despite successful primary treatment of nasopharyngeal carcinoma (NPC), the
incidence of distant metastasis remains 25–34%. Treatment options are limited, and survival …

Purpose: To determine the toxicity, tolerability, pharmacokinetics, pharmacodynamics, and
preliminary antitumor activity of oral gemcitabine (2′, 2′-difluorodeoxycytidine; dFdC) in …

Purpose To develop a sensitive analytical method to quantify gemcitabine (2′, 2′-
difluorodeoxycytidine, dFdC) and its metabolites 2′, 2′-difluorodeoxyuridine (dFdU) and …

Synthetic nucleotide and nucleic acid analogues are useful research tools and modern
therapeutics. Hence, methods for the rapid and unambiguous identification of …

Aims Gemcitabine (2′, 2′‐difluoro‐2′‐deoxycytidine; dFdC) is a prodrug that has to be
phosphorylated within the tumour cell to become active. Intracellularly formed gemcitabine …