One of the recently emerging topics in biotechnology is natural receptors including G protein-
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …

G-protein-coupled receptors (GPCRs) are of prime importance for cell signal transduction
mechanisms and are the target of many current and potential drugs. However, structural …

In order to obtain a novel binding protein against a chosen target, DNA molecules, each
encoding a protein comprising one of a family of similar potential binding domains and a …

In order to obtain a novel binding protein against a chosen target, DNA molecules, each
encoding a protein comprising one of a family of similar potential binding domains and a …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
27399321&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

The turkey beta-adrenergic receptor (beta-AR), the m1 and m2 forms of the human
muscarinic cholingeric receptor (MAChR) and several other mutant and wild-type G protein …

In Escherichia coli and other cell-based expression systems, there are critical difficulties in
synthesizing membrane proteins, such as the low protein expression levels and the …

With the goal of obtaining sufficient quantities of seven-helix G-protein-coupled receptors for
structural analysis, we have studied the functional expression of a rat neurotensin receptor …

For large-scale production, as required in structural biology, membrane proteins can be
expressed in an insoluble form as inclusion bodies and be refolded in vitro. This requires …

Signaling through serotonin 5-HT1A receptors involves multiple pathways. We have
investigated the functional coupling of the human 5-HT1A receptor to different G proteins …