Simple Summary Glioblastoma multiforme (GBM) is one of the most aggressive
malignancies, accounting for 14.5% of all central nervous system tumors and 48.6% of …

Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However,
the mechanism by which this occurs has not yet been uncovered. Here, we investigated the …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in
cancer patients. In order to effectively escape the tumour, enter the circulation and establish …

Increases in intracellular free Ca 2+ play a major role in many cellular processes. The
deregulation of Ca 2+ signaling is a feature of a variety of diseases, and modulators of Ca …

Electromagnetic fields (EMF) are increasing in popularity as a safe and non-invasive
therapy. On the one hand, it is widely acknowledged that EMF can regulate the proliferation …

In the absence of low-level ER-to-mitochondrial Ca 2+ transfer, ATP levels fall, and AMPK-
dependent, mTOR-independent autophagy is induced as an essential survival mechanism …