Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …

Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

Normal aging is accompanied by escalating systemic inflammation. Yet the potential impact
of immune homeostasis on neurogenesis and cognitive decline during brain aging have not …

Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …

Inflammatory mediators affect the brain during development. Neurodevelopmental disorders
such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and …

Aging drives cognitive and regenerative impairments in the adult brain, increasing
susceptibility to neurodegenerative disorders in healthy individuals,,,. Experiments using …

Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

Evidence from clinical, preclinical, and post-mortem studies supports the
inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident is the link …