Heterochromatin: guardian of the genome
A Janssen, SU Colmenares… - Annual review of cell and …, 2018 - annualreviews.org
Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
[HTML][HTML] A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping
We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and
diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 …
diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 …
Genome architecture: domain organization of interphase chromosomes
WA Bickmore, B Van Steensel - Cell, 2013 - cell.com
The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …
A census of human transcription factors: function, expression and evolution
Transcription factors are key cellular components that control gene expression: their
activities determine how cells function and respond to the environment. Currently, there is …
activities determine how cells function and respond to the environment. Currently, there is …
Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers
Increasing evidence suggests that durable drug-free control of HIV-1 replication is enabled
by effective cellular immune responses that may induce an attenuated viral reservoir …
by effective cellular immune responses that may induce an attenuated viral reservoir …
Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence
W Meuleman, D Peric-Hupkes, J Kind… - Genome …, 2013 - genome.cshlp.org
In metazoans, the nuclear lamina is thought to play an important role in the spatial
organization of interphase chromosomes, by providing anchoring sites for large genomic …
organization of interphase chromosomes, by providing anchoring sites for large genomic …
Proximity RNA labeling by APEX-seq reveals the organization of translation initiation complexes and repressive RNA granules
A Padrón, S Iwasaki, NT Ingolia - Molecular cell, 2019 - cell.com
Diverse ribonucleoprotein complexes control mRNA processing, translation, and decay.
Transcripts in these complexes localize to specific regions of the cell and can condense into …
Transcripts in these complexes localize to specific regions of the cell and can condense into …
Genomic and proteomic resolution of heterochromatin and its restriction of alternate fate genes
Heterochromatin is integral to cell identity maintenance by impeding the activation of genes
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …