The amount of single-cell RNA-sequencing (scRNA-seq) data produced in the field of
human male reproduction has steadily increased. Transcriptional profiles of thousands of …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

Advanced paternal age is associated with an increased risk of fathering children with
genetic disorders and other adverse reproductive consequences. However, the mechanisms …

Klinefelter Syndrome (KS) is characterized by a masculine phenotype, supernumerary sex
chromosomes (47, XXY), and impaired fertility due to loss of spermatogonial stem cells …

Nonobstructive azoospermia (NOA) is one of the most important causes of male infertility,
accounting for 10–15% of infertile men worldwide. Among these, more than 70% of cases …

Antineoplastic treatments for cancer and other non-malignant disorders can result in long-
term or permanent male infertility by ablating spermatogonial stem cells (SSCs). SSC …

The process of spermatogenesis—when germ cells differentiate into sperm—is tightly
regulated, and misregulation in gene expression is likely to be involved in the …

Male infertility has emerged as a global issue, partly attributed to psychological stress.
However, the cellular and molecular mechanisms underlying the adverse effects of …

Background Infertility affects around 15% of all couples worldwide and is increasingly linked
to variants in genes specifically expressed in the testis. Well‐established causes of male …

Background 1 Microfluidic techniques have emerged as powerful tools in single-cell
research, facilitating the exploration of omics information from individual cells. Cell …