ARF GTPases and their GEFs and GAPs: concepts and challenges
E Sztul, PW Chen, JE Casanova… - Molecular biology of …, 2019 - Am Soc Cell Biol
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …
required to develop models of its actions in cells. Studying a protein family in the aggregate …
ARF proteins: roles in membrane traffic and beyond
C D'Souza-Schorey, P Chavrier - Nature reviews Molecular cell biology, 2006 - nature.com
The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is
activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show …
activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show …
Endocytosis and molecular sorting
I Mellman - Annual review of cell and developmental biology, 1996 - annualreviews.org
▪ Abstract Endocytosis in eukaryotic cells is characterized by the continuous and regulated
formation of prolific numbers of membrane vesicles at the plasma membrane. These …
formation of prolific numbers of membrane vesicles at the plasma membrane. These …
Cargo recognition in clathrin-mediated endocytosis
LM Traub, JS Bonifacino - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
The endosomal system is expansive and complex, characterized by swift morphological
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …
Mechanisms of intracellular protein transport
JE Rothman - Nature, 1994 - nature.com
Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …
AP2 controls clathrin polymerization with a membrane-activated switch
BT Kelly, SC Graham, N Liska, PN Dannhauser… - Science, 2014 - science.org
Clathrin-mediated endocytosis (CME) is vital for the internalization of most cell-surface
proteins. In CME, plasma membrane–binding clathrin adaptors recruit and polymerize …
proteins. In CME, plasma membrane–binding clathrin adaptors recruit and polymerize …
Protein sorting by transport vesicles
JE Rothman, FT Wieland - Science, 1996 - science.org
Eukaryotic life depends on the spatial and temporal organization of cellular membrane
systems. Recent advances in understanding the machinery of vesicle transport have …
systems. Recent advances in understanding the machinery of vesicle transport have …
Clathrin-coated vesicle formation and protein sorting: an integrated process
SL Schmid - Annual review of biochemistry, 1997 - annualreviews.org
Clathrin-coated vesicles were the first discovered and remain the most extensively
characterized transport vesicles. They mediate endocytosis of transmembrane receptors and …
characterized transport vesicles. They mediate endocytosis of transmembrane receptors and …
[HTML][HTML] Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi
YJ Wang, J Wang, HQ Sun, M Martinez, YX Sun… - Cell, 2003 - cell.com
Abstract Phosphatidylinositol 4 phosphate [PI (4) P] is essential for secretion in yeast, but its
role in mammalian cells is unclear. Current paradigms propose that PI (4) P acts primarily as …
role in mammalian cells is unclear. Current paradigms propose that PI (4) P acts primarily as …