Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is
activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show …

▪ Abstract Endocytosis in eukaryotic cells is characterized by the continuous and regulated
formation of prolific numbers of membrane vesicles at the plasma membrane. These …

The endosomal system is expansive and complex, characterized by swift morphological
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …

Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …

Clathrin-mediated endocytosis (CME) is vital for the internalization of most cell-surface
proteins. In CME, plasma membrane–binding clathrin adaptors recruit and polymerize …

Eukaryotic life depends on the spatial and temporal organization of cellular membrane
systems. Recent advances in understanding the machinery of vesicle transport have …

Clathrin-coated vesicles were the first discovered and remain the most extensively
characterized transport vesicles. They mediate endocytosis of transmembrane receptors and …

Abstract Phosphatidylinositol 4 phosphate [PI (4) P] is essential for secretion in yeast, but its
role in mammalian cells is unclear. Current paradigms propose that PI (4) P acts primarily as …