Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …
have modified their virulence mechanisms to adapt to host defense systems. Although the …
How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
The pleiotropic two-component regulatory system PhoP-PhoQ
EA Groisman - Journal of bacteriology, 2001 - Am Soc Microbiol
PhoP-PhoQ is a two-component system that governs virulence, mediates the adaptation to
Mg2+-limiting environments, and regulates numerous cellular activities in several gram …
Mg2+-limiting environments, and regulates numerous cellular activities in several gram …
Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …
highly engage into research on alternative strategies to the traditional small molecule …
Bacterial strategies of resistance to antimicrobial peptides
Antimicrobial peptides (AMPs) are a key component of the host's innate immune system,
targeting invasive and colonizing bacteria. For successful survival and colonization of the …
targeting invasive and colonizing bacteria. For successful survival and colonization of the …
Bacterial Mg2+ Homeostasis, Transport, and Virulence
EA Groisman, K Hollands, MA Kriner… - Annual review of …, 2013 - annualreviews.org
Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical
for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and …
for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and …
The Mycobacterium tuberculosis PhoPR two‐component system regulates genes essential for virulence and complex lipid biosynthesis
SB Walters, E Dubnau, I Kolesnikova… - Molecular …, 2006 - Wiley Online Library
Two‐component signal transduction systems (2‐CS) play an important role in bacterial
pathogenesis. In the work presented here, we have studied the effects of a mutation in the …
pathogenesis. In the work presented here, we have studied the effects of a mutation in the …
An essential role for phoP in Mycobacterium tuberculosis virulence
E Pérez, S Samper, Y Bordas, C Guilhot… - Molecular …, 2001 - Wiley Online Library
Two‐component regulatory proteins function in bacteria as sensory and adaptive factors in
response to a wide range of environmental stimuli. Some two‐component systems, such as …
response to a wide range of environmental stimuli. Some two‐component systems, such as …
The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more
JS Gunn - Trends in microbiology, 2008 - cell.com
Microbes are able to sense and respond to their environment primarily through the use of
two-component regulatory systems. Many of these systems activate virulence-factor …
two-component regulatory systems. Many of these systems activate virulence-factor …