Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

A Beceiro, M Tomás, G Bou - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution

EA Groisman, A Duprey, J Choi - Microbiology and Molecular …, 2021 - Am Soc Microbiol
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

The pleiotropic two-component regulatory system PhoP-PhoQ

EA Groisman - Journal of bacteriology, 2001 - Am Soc Microbiol
PhoP-PhoQ is a two-component system that governs virulence, mediates the adaptation to
Mg2+-limiting environments, and regulates numerous cellular activities in several gram …

Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Bacterial strategies of resistance to antimicrobial peptides

HS Joo, CI Fu, M Otto - … of the Royal Society B: Biological …, 2016 - royalsocietypublishing.org
Antimicrobial peptides (AMPs) are a key component of the host's innate immune system,
targeting invasive and colonizing bacteria. For successful survival and colonization of the …

Bacterial Mg2+ Homeostasis, Transport, and Virulence

EA Groisman, K Hollands, MA Kriner… - Annual review of …, 2013 - annualreviews.org
Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical
for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and …

The Mycobacterium tuberculosis PhoPR two‐component system regulates genes essential for virulence and complex lipid biosynthesis

SB Walters, E Dubnau, I Kolesnikova… - Molecular …, 2006 - Wiley Online Library
Two‐component signal transduction systems (2‐CS) play an important role in bacterial
pathogenesis. In the work presented here, we have studied the effects of a mutation in the …

An essential role for phoP in Mycobacterium tuberculosis virulence

E Pérez, S Samper, Y Bordas, C Guilhot… - Molecular …, 2001 - Wiley Online Library
Two‐component regulatory proteins function in bacteria as sensory and adaptive factors in
response to a wide range of environmental stimuli. Some two‐component systems, such as …

The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more

JS Gunn - Trends in microbiology, 2008 - cell.com
Microbes are able to sense and respond to their environment primarily through the use of
two-component regulatory systems. Many of these systems activate virulence-factor …

Plague

MB Prentice, L Rahalison - The Lancet, 2007 - thelancet.com
Bubonic plague is an often fulminant systemic zoonosis, caused by Yersinia pestis.
Conventional microbiology, bacterial population genetics, and genome sequence data, all …