The enzymes of both de novo and salvage pathways for purine nucleotide synthesis are
regulated to meet the demand of nucleic acid precursors during proliferation. Among them …

The growing evidence of the involvement of purine compounds in signaling, of nucleotide
imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light …

Introduction: Ectonucleotidases are a broad family of metallo-ectoenzymes that are
responsible for hydrolysing a variety of nucleotides to nucleosides, hence orchestrating the …

Background. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors
in the world, and its incidence is obviously increasing. The NT5DC family has been shown to …

Purpose Purine metabolism involves various intracellular and extracellular enzymes,
including cN-II and CD73 that dephosphorylate intracellular and extracellular nucleoside …

We used a combined approach based on fragment-based drug design (FBDD) and in silico
methods to design potential inhibitors of the cytosolic 5′-nucleotidase II (cN-II), which has …

Purine homeostasis is maintained by a purine cycle in which the regulated member is a
cytosolic 5′-nucleotidase II (cN-II) hydrolyzing IMP and GMP. Its expression is particularly …

Abstract The cytosolic 5'-nucleotidase cN-II is a highly conserved enzyme implicated in
nucleotide metabolism. Based on recent observations suggesting additional roles not …

Nucleotide metabolism is the target of a large number of anticancer drugs including
antimetabolites and specific enzyme inhibitors. We review scientific findings that over the …

Cytosolic 5′-nucleotidase II (NT5C2) is a highly regulated enzyme involved in the
maintenance of intracellular purine and the pyrimidine compound pool. It dephosphorylates …