Insulin resistance is a systemic disorder that affects many organs and insulin-regulated
pathways. The disorder is characterized by a reduced action of insulin despite increased …

Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Diabetes is associated with β cell failure. But it remains unclear whether the latter results
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …

Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …

Following a previous genome-wide association study (GWAS 1) including 744 cases and
895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese …

New therapeutic approaches to counter the increasing prevalence of obesity and type 2
diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase …

In animal models, the physiological systems involved in metabolic homeostasis exhibit a sex
difference. Investigators often use male rodents because they show metabolic disease better …

Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X)
have become global health epidemics. Over the past decade, the elucidation of key …

Previous studies have shown that insulin and IGF-1 signaling in the brain, especially the
hypothalamus, is important for regulation of systemic metabolism. Here, we develop mice in …