Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Liver fibrosis is a wound-healing response generated against an insult to the liver that
causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may …

Although macrophages are widely recognized to have a profibrotic role in inflammation, we
have used a highly tractable CCl4-induced model of reversible hepatic fibrosis to identify …

The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Matrix rigidity has important effects on cell behavior and is increased during liver fibrosis;
however, its effect on primary hepatocyte function is unknown. We hypothesized that …

Portal hypertension and bleeding from gastroesophageal varices is the major cause of
morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased …