Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …

INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Both microbial and host genetic factors contribute to the pathogenesis of autoimmune
diseases,,,. There is accumulating evidence that microbial species that potentiate chronic …

Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from
pathogenic microbes but are also prominent effectors of inflammation and autoimmune …

Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Summary Whether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut
mucosa is controversial and few studies have analyzed specific cell populations for …

RORγt+ Th17 cells are important for mucosal defenses but also contribute to autoimmune
disease. They accumulate in the intestine in response to microbiota and produce IL-17 …