Hepatocellular carcinoma (HCC), the most common form of primary liver cancer is the third
leading cause of cancer-related cell death in human and the fifth in women worldwide. The …

Biliary tract cancers (BTCs) are aggressive epithelial malignancies that can arise at any
point of the biliary tree. Albeit rare, their incidence and mortality rates have been rising …

Transcription activator-like effector nucleases (TALENs) are programmable nucleases that
join FokI endonuclease with the modular DNA-binding domain of TALEs. Although zinc …

Abstract The Sleeping Beauty (SB) transposon is a promising technology platform for gene
transfer in vertebrates; however, its efficiency of gene insertion can be a bottleneck in …

Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that
drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have …

The p53 tumor suppressor coordinates a series of antiproliferative responses that restrict the
expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority of …

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide
which lacks effective treatment. Cancer cells experience high levels of oxidative stress due …

A segmental deletion resulting in DNAJB1–PRKACA gene fusion is now recognized as the
signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal …

Cancers grow within tissues through molecular mechanisms still unclear. Invasiveness
correlates with perturbed O-glycosylation, a covalent modification of cell-surface proteins …

We describe a system that permits conditional mobilization of a Sleeping Beauty (SB)
transposase allele by Cre recombinase to induce cancer specifically in a tissue of interest …