Septic shock, the most severe complication of sepsis, accounts for∼ 10% of all admissions
to intensive care. Our understanding of its complex pathophysiology remains incomplete but …

The molecular background of the Ca2+-sensitizing effect of levosimendan relates to its
specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments …

A informação farmacológica essencial de que você precisa–para seu estudo, pesquisa e
atividades profissionais! Durante 25 anos, Rang & Dale Farmacologia tem fornecido a …

Objective: Catecholaminergic inotropes have a place in the management of low output
syndrome and decompensated heart failure but their effect on mortality is debated …

Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

Levosimendan is a new calcium sensitizer and K-ATP channel opener. Compared with other
inodilators, it improves myocardial contractility without increasing oxygen requirements and …

or myocyte alkalization. This type of change would primarily manifest in normal operating
ranges of Ca2 activation. A potential problem is that force generation is also greater at …

Purpose There is controversy about the use of inotropes in the treatment of severe sepsis
and septic shock. The objective of this study was to evaluate if levosimendan, as compared …

Mass spectrometry-based chemoproteomics has emerged as an enabling technology for
functional biology and drug discovery. To address limitations of established …

Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality. Right
ventricular function is the most important predictor of morbidity and mortality in patients …