[HTML][HTML] Guanosine: a neuromodulator with therapeutic potential in brain disorders
D Lanznaster, T Dal-Cim, TCB Piermartiri… - Aging and …, 2016 - ncbi.nlm.nih.gov
Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …
protective role in response to degenerative diseases or injury. The past decade has seen …
PI3K/AKT/PTEN pathway as a target for Crohn's disease therapy
N Tokuhira, Y Kitagishi, M Suzuki… - International …, 2015 - spandidos-publications.com
The pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease, is a
subject of increasing interest. Loss-of-function mutations in nucleotide‑binding …
subject of increasing interest. Loss-of-function mutations in nucleotide‑binding …
[HTML][HTML] Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β …
Mitochondrial perturbation and oxidative stress are key factors in neuronal vulnerability in
several neurodegenerative diseases or during brain ischemia. Here we have investigated …
several neurodegenerative diseases or during brain ischemia. Here we have investigated …
Guanosine prevents oxidative damage and glutamate uptake impairment induced by oxygen/glucose deprivation in cortical astrocyte cultures: Involvement of A 1 and …
T Dal-Cim, GG Poluceno, D Lanznaster… - Purinergic …, 2019 - Springer
Glial cells are involved in multiple cerebral functions that profoundly influence brain tissue
viability during ischemia, and astrocytes are the main source of extracellular purines as …
viability during ischemia, and astrocytes are the main source of extracellular purines as …
Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions
T Dal‐Cim, FK Ludka, WC Martins… - Journal of …, 2013 - Wiley Online Library
Guanosine (GUO) is an endogenous modulator of glutamatergic excitotoxicity and has been
shown to promote neuroprotection in in vivo and in vitro models of neurotoxicity. This study …
shown to promote neuroprotection in in vivo and in vitro models of neurotoxicity. This study …
[HTML][HTML] Neuromodulatory effects of guanine-based purines in health and disease
CI Tasca, D Lanznaster, KA Oliveira… - Frontiers in cellular …, 2018 - frontiersin.org
The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide–cGMP and PI3K/mTOR pathways
Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …
glutamatergic transmission and neuroprotection. The present study evaluated the …
Guanosine anxiolytic-like effect involves adenosinergic and glutamatergic neurotransmitter systems
RF Almeida, DD Comasseto, DB Ramos… - Molecular …, 2017 - Springer
Accumulating evidences indicate that endogenous modulators of excitatory synapses in the
mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed …
mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed …
Purine nucleosides in neuroregeneration and neuroprotection
FF Ribeiro, S Xapelli, C Miranda-Lourenco… - …, 2016 - Elsevier
In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …
Augmentation effect of ketamine by guanosine in the novelty-suppressed feeding test is dependent on mTOR signaling pathway
The ketamine's potential for the treatment of refractory depression and anxiety has been
considered one the most important discoveries in the last years, however, repeated use of …
considered one the most important discoveries in the last years, however, repeated use of …