Apoptosis or programmed cell death is a key regulator of physiological growth control and
regulation of tissue homeostasis. One of the most important advances in cancer research in …

The inactivation of programmed cell death, or apoptosis, is central to the development of
cancer. This disabling of apoptotic responses might be a major contributor both to treatment …

The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by
John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

MicroRNAs (miRNAs) have recently emerged as an important new class of cellular
regulators that control various cellular processes and are implicated in human diseases …

Originally described in insect viruses, cellular proteins with Baculoviral IAP repeat (BIR)
motifs have been thought to function primarily as inhibitors of apoptosis. The subsequent …

TP53 wild-type breast tumors rarely undergo a complete pathological response after
chemotherapy treatment. These patients have an extremely poor survival rate and studies …

Although TP53 mutations are rare in acute myeloid leukemia (AML), inactivation of wild-type
p53 protein frequently occurs through overexpression of its negative regulator MDM2 …

Chromosomal region maintenance 1 (CRM1) is a nuclear export receptor recognizing
proteins bearing a leucine-rich nuclear export signal. CRM1 is involved in nuclear export of …

Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to
expand even in a stressful environment. Cells resistant to apoptosis are also assumed to be …