[HTML][HTML] The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies
Y Zhang, J Liang, P Liu, Q Wang, L Liu… - Frontiers in …, 2022 - frontiersin.org
With the markedly increased diagnosis and incidence of cancer in the population, tumor
bone metastasis has become a frequent event in tumor patients. Healthy bone integrity is …
bone metastasis has become a frequent event in tumor patients. Healthy bone integrity is …
The RANK–RANKL–OPG System: A Multifaceted Regulator of Homeostasis, Immunity, and Cancer
D De Leon-Oliva, S Barrena-Blázquez… - Medicina, 2023 - mdpi.com
The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in
bone metabolism, mammary epithelial cell development, immune function, and cancer …
bone metabolism, mammary epithelial cell development, immune function, and cancer …
lncRNA MALAT1 Regulates the Resistance of Breast Cancer Cells to Paclitaxel Via the miR-497-5p/ SHOC2 axis
C Shi, S Ren, X Zhao, Q Li - Pharmacogenomics, 2022 - Taylor & Francis
Aim: To explore the roles of lncRNA MALAT1 and SHOC2 in breast cancer, and the potential
connections to chemotherapy resistance in breast cancer. Materials & methods: Paclitaxel …
connections to chemotherapy resistance in breast cancer. Materials & methods: Paclitaxel …
A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer …
T Ge, Z Weiwei, F Ge, L Zhu, P Song, W Li, L Gui… - Biomaterials …, 2022 - pubs.rsc.org
Chemotherapy is a conventional treatment method for metastatic bone cancer, but it has
limitations, such as lower drug-targeting of bone tissues and serious side effects. Bone …
limitations, such as lower drug-targeting of bone tissues and serious side effects. Bone …
Management of pain in patients with bone metastases
D Jing, Q Zhao, Y Zhao, X Lu, Y Feng, B Zhao… - Frontiers in …, 2023 - frontiersin.org
Cancer-induced bone pain (CIBP) has a considerable impact on patients' quality of life as
well as physical and mental health. At present, patients with CIBP are managed according to …
well as physical and mental health. At present, patients with CIBP are managed according to …
Exploring the Interplay of RUNX2 and CXCR4 in Melanoma Progression
L Dalle Carbonare, A Minoia, A Vareschi, FC Piritore… - Cells, 2024 - mdpi.com
Overexpression of the Runt-related transcription factor 2 (RUNX2) has been reported in
several cancer types, and the CXC motif chemokine receptor 4 (CXCR4) has an important …
several cancer types, and the CXC motif chemokine receptor 4 (CXCR4) has an important …
CD105 expression in cancer-associated fibroblasts: a biomarker for bone metastasis in early invasive ductal breast cancer patients
MB Giorello, LM Martinez, FR Borzone… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Bone metastasis is one of the causes that mainly decrease survival in patients
with advanced breast cancer. Therefore, it is essential to find prognostic markers for the …
with advanced breast cancer. Therefore, it is essential to find prognostic markers for the …
[HTML][HTML] MiR-30 Family: A Novel Avenue for Treating Bone and Joint Diseases?
J Huang, Y Li, S Zhu, L Wang, L Yang… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Bone and joint diseases are a group of clinically heterogeneous diseases characterized by
various bone strength disorders, bone structural defects and bone mass abnormalities …
various bone strength disorders, bone structural defects and bone mass abnormalities …
Targeting nerve growth factor-mediated osteosarcoma metastasis: mechanistic insights and therapeutic opportunities using larotrectinib
CH Hou, WL Chen, CY Lin - Cell Death & Disease, 2024 - nature.com
Osteosarcoma (OS) therapy presents numerous challenges, due largely to a low survival
rate following metastasis onset. Nerve growth factor (NGF) has been implicated in the …
rate following metastasis onset. Nerve growth factor (NGF) has been implicated in the …
A Novel Algorithm for Evaluating Bone Metastatic Potential of Breast Cancer through Morphometry and Computational Mathematics
SA Duca-Barbu, AA Bratei, AC Lisievici, TA Georgescu… - Diagnostics, 2023 - mdpi.com
Bone metastases represent about 70% of breast cancer metastases and are associated with
worse prognosis as the tumor cells acquire more aggressive features. The selection and …
worse prognosis as the tumor cells acquire more aggressive features. The selection and …