Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …

Background Many patients with psoriatic arthritis have an inadequate response to tumor
necrosis factor (TNF) inhibitors. Guselkumab, a specific inhibitor of interleukin-23 (IL-23) via …

The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …

Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …

Neutrophils perform critical functions in the innate response to infection, including through
the production of neutrophil extracellular traps (NETs)-web-like DNA structures which are …

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous
system (CNS) lesions that can lead to severe physical or cognitive disability as well as …

Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …

Objectives Previous studies have reported that a few inflammatory cytokines have
associations with systemic lupus erythematosus (SLE)—for example, IL-6, IL-17, and …