[HTML][HTML] Crosstalk of inflammatory cytokines within the breast tumor microenvironment
O Habanjar, R Bingula, C Decombat… - International journal of …, 2023 - mdpi.com
Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …
[HTML][HTML] Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …
central to the balance between immune tolerance and immune rejection. Th cells adopt …
[HTML][HTML] Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …
Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind …
A Deodhar, PS Helliwell, WH Boehncke, AP Kollmeier… - The Lancet, 2020 - thelancet.com
Background Many patients with psoriatic arthritis have an inadequate response to tumor
necrosis factor (TNF) inhibitors. Guselkumab, a specific inhibitor of interleukin-23 (IL-23) via …
necrosis factor (TNF) inhibitors. Guselkumab, a specific inhibitor of interleukin-23 (IL-23) via …
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
JM Pickard, MY Zeng, R Caruso… - Immunological …, 2017 - Wiley Online Library
The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …
[HTML][HTML] Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review
A Strzelak, A Ratajczak, A Adamiec… - International journal of …, 2018 - mdpi.com
Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …
responses contributing to the development of chronic obstructive pulmonary disease …
[HTML][HTML] Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2
AS Wilson, KL Randall, JA Pettitt, JI Ellyard… - Nature …, 2022 - nature.com
Neutrophils perform critical functions in the innate response to infection, including through
the production of neutrophil extracellular traps (NETs)-web-like DNA structures which are …
the production of neutrophil extracellular traps (NETs)-web-like DNA structures which are …
[HTML][HTML] Multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous
system (CNS) lesions that can lead to severe physical or cognitive disability as well as …
system (CNS) lesions that can lead to severe physical or cognitive disability as well as …
T helper cell differentiation, heterogeneity, and plasticity
J Zhu - Cold Spring Harbor perspectives in biology, 2018 - cshperspectives.cshlp.org
Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …
[HTML][HTML] Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: A Mendelian randomization
M Xiang, Y Wang, Z Gao, J Wang, Q Chen… - Frontiers in …, 2023 - frontiersin.org
Objectives Previous studies have reported that a few inflammatory cytokines have
associations with systemic lupus erythematosus (SLE)—for example, IL-6, IL-17, and …
associations with systemic lupus erythematosus (SLE)—for example, IL-6, IL-17, and …