Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …

Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic
stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke …

Disorders of brain glucose metabolism is known to affect brain activity in neurodegenerative
diseases including Alzheimer's disease (AD). Furthermore, recent evidence has shown an …

Chronic hypertension is one of the key modifiable risk factors for acute ischemic stroke, also
contributing to determine greater neurological deficits and worse functional outcome when …

Alterations in mitochondrial functions have been hypothesized to participate in the
pathogenesis of depression, because brain bioenergetic abnormalities have been detected …

Brain bioenergetic abnormalities in mood disorders were detected by neuroimaging in vivo
studies in humans. Because of the increasing importance of mitochondrial pathogenetic …

Glutamate is involved in cerebral ischemic injury, but its role has not been completely
clarified and studies are required to understand how to minimize its detrimental effects …

In this study the subcellular modifications undergone by cerebral cortex mitochondrial
metabolism in chronic hypertension during aging were evaluated. The catalytic properties of …

Synaptic energy state and mitochondrial dysfunction are crucial factors in many brain
pathologies. l-acetylcarnitine, a natural derivative of carnitine, improves brain energy …

Clonidine is an anti-hypertensive drug that inhibits the release of norepinephrine from pre-
synaptic terminals binding to pre-synaptic α2-adrenoreceptors. Some studies suggest that …