Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET)
radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear …

Caspases are proteases at the heart of networks that govern apoptosis and inflammation.
The past decade has seen huge leaps in understanding the biology and chemistry of the …

BACKGROUND: Lateral ventricular enlargement is one of the most consistent findings in
patients with schizophrenia; however whether progressive ventricular dilation occurs during …

Cell death is a critically important biological process. Disruption of homeostasis, either by
excessive or deficient cell death, is a hallmark of many pathological conditions. Recent …

Of the molecular biochemical alterations that occur during apoptosis, activation of caspases,
notably caspase-3, is probably the most attractive for developing specific in vivo molecular …

Positron emission tomography (PET) is a powerful noninvasive molecular imaging
technique that uses molecules labeled with positron-emitting isotopes such as carbon-11 …

Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …

Apoptosis is a fundamental biologic process. Molecular imaging of apoptosis in vivo may
have important implications for clinical practice, assisting in early detection of disease …

Purpose Early assessment of tumor response to therapy is vital for treatment optimization for
the individual cancer patient. Induction of apoptosis is an early and nearly universal effect of …

Purpose We tested whether positron emission tomography (PET) with the caspase-3-
targeted isatin analog [18 F] WC-4-116 could image caspase-3 activation in response to an …