The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …

Leptin is a hormone released by adipose tissue that plays a key role in the control of energy
homeostasis through its binding to leptin receptors (LepR), mainly expressed in the …

Background: Sedentary lifestyles, urbanization and improvements in socio-economic status
have had serious effects on the burden of diabetes across the world. Diabetes is one of the …

Objective Gestational diabetes mellitus (GDM) is a metabolic disorder that shares
pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to …

Objectives Obesity is a major risk factor in aetiology of type 2 diabetes mellitus (T2DM).
Leptin (LEP) is an anti-obesity hormone which regulates food intake, energy expenditure …

Aim Critically discuss the available data, to identify the current gaps and to provide key
concepts that will help clinicians in translating the biology of adipokines in the context of …

Leptin is a hormone protein regulating food intake and energy expenditure. A number of
studies have evaluated the genetic effect of leptin (LEP) and leptin receptor (LEPR) genes …

Adipokine Profile in Patients with Type 2 Diabetes Depends on Degree of Obesity - PMC Back
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Results: The most prevalent leptin/leptin receptor genes (LEP/LEPR) and ghrelin/ghrelin
receptor genes (GHRL/GHSR) single nucleotide polymorphisms studied were LEP G …

Adipose tissue is an extremely active organ, and plays a fundamental role in the genesis of
comorbidities associated with obesity. Since the discovery of leptin, an important focus has …