Isatin–azole hybrids and their anticancer activities
Y Hou, C Shang, H Wang, J Yun - Archiv der Pharmazie, 2020 - Wiley Online Library
Isatin and azole moieties, which have the ability to form various noncovalent interactions
with different therapeutic targets, are common pharmacophores in drug development. Isatin …
with different therapeutic targets, are common pharmacophores in drug development. Isatin …
An approach to pharmacological targets of pyrrole family from medicinal chemistry viewpoint
ES Moghadam, K Mireskandari… - Mini Reviews in …, 2022 - ingentaconnect.com
Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to
the importance of pyrrole structure in drug design and development, herein, we tried to …
the importance of pyrrole structure in drug design and development, herein, we tried to …
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
Design, synthesis, biological assessment and molecular docking studies of new 2-aminoimidazole-quinoxaline hybrids as potential anticancer agents
Z Ghanbarimasir, A Bekhradnia… - … Acta Part A: Molecular …, 2018 - Elsevier
In a search for novel antiproliferative agents, a series of quinoxaline derivatives containing 2-
aminoimidazole (8a–8x) were designed and synthesized. The structures of synthesized …
aminoimidazole (8a–8x) were designed and synthesized. The structures of synthesized …
[HTML][HTML] Computationally repurposing drugs for breast cancer subtypes using a network-based approach
Abstract 'De novo'drug discovery is costly, slow, and with high risk. Repurposing known
drugs for treatment of other diseases offers a fast, low-cost/risk and highly-efficient method …
drugs for treatment of other diseases offers a fast, low-cost/risk and highly-efficient method …
Green synthesis, biological activity evaluation, and molecular docking studies of aryl alkylidene 2, 4-thiazolidinedione and rhodanine derivatives as antimicrobial …
M Akhavan, N Foroughifar, H Pasdar… - … Chemistry & High …, 2019 - ingentaconnect.com
Aims and Objective: The magic scaffolds rhodanine and thiazolidine are very important
heterocyclic compounds in drug design and discovery. Those are important heterocyclic …
heterocyclic compounds in drug design and discovery. Those are important heterocyclic …
Cell cycle inhibition, apoptosis, and molecular docking studies of the novel anticancer bioactive 1, 2, 4-triazole derivatives
J Ghanaat, MA Khalilzadeh, D Zareyee… - Structural Chemistry, 2020 - Springer
Abstract Several 3-alkylsulfanyl-1, 2, 4-triazole derivatives were synthesized and their
relevant structures confirmed based on their elemental analysis and nuclear magnetic …
relevant structures confirmed based on their elemental analysis and nuclear magnetic …
Thiazole, isatin and phthalimide derivatives tested in vivo against cancer models: a literature review of the last six years
AF Pinto, JS Nunes, JE Severino Martins… - Current Medicinal …, 2024 - ingentaconnect.com
Background: Cancer is a disease characterized by the abnormal multiplication of cells and is
the second leading cause of death in the world. The search for new effective and safe …
the second leading cause of death in the world. The search for new effective and safe …
Targeting Tyrosine kinase: Development of acridone–pyrrole–oxindole hybrids against human breast cancer
M Kaur, P Singh - Bioorganic & medicinal chemistry letters, 2019 - Elsevier
Based on the molecular modelling studies, a rational modification of the lead molecule was
made to develop highly potent compounds showing anti-cancer activity against human …
made to develop highly potent compounds showing anti-cancer activity against human …
Leveraging shape screening and molecular dynamics simulations to optimize PARP1-Specific chemo/radio-potentiators for antitumor drug design
H Khizer, A Maryam, A Ansari, MS Ahmad… - Archives of Biochemistry …, 2024 - Elsevier
PARP1 plays a pivotal role in DNA repair within the base excision pathway, making it a
promising therapeutic target for cancers involving BRCA mutations. Current study is focused …
promising therapeutic target for cancers involving BRCA mutations. Current study is focused …