Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Organelles are critical structures in mediating the assembly and activation of
inflammasomes in mammalian cells, resulting in inflammation and cell death. Assembly of …

Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

In addition to their intracellular mobility, mitochondria and their components can exist
outside the cells from which they originate. As a result, they are capable of acting on non …

Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular
energetics and which on the other is a ubiquitous signaling molecule when released into the …

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …