Understanding virus structure and dynamics through molecular simulations
Viral outbreaks remain a serious threat to human and animal populations and motivate the
continued development of antiviral drugs and vaccines, which in turn benefits from a …
continued development of antiviral drugs and vaccines, which in turn benefits from a …
The dynamics of viruslike capsid assembly and disassembly
SBPE Timmermans, A Ramezani… - Journal of the …, 2022 - ACS Publications
Cowpea chlorotic mottle virus (CCMV) is a widely used model for virus replication studies. A
major challenge lies in distinguishing between the roles of the interaction between coat …
major challenge lies in distinguishing between the roles of the interaction between coat …
Synthesis, insertion, and characterization of SARS-CoV-2 membrane protein within lipid bilayers
Throughout history, coronaviruses have posed challenges to both public health and the
global economy; nevertheless, methods to combat them remain rudimentary, primarily due …
global economy; nevertheless, methods to combat them remain rudimentary, primarily due …
Kinetic growth of multicomponent microcompartment shells
An important goal of systems and synthetic biology is to produce high value chemical
species in large quantities. Microcompartments, which are protein nanoshells encapsulating …
species in large quantities. Microcompartments, which are protein nanoshells encapsulating …
Biophysical modeling of SARS-CoV-2 assembly: Genome condensation and budding
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and …
(SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and …
Over two decades of research on the marine RNA virosphere
Abstract RNA viruses (realm: Riboviria), including RNA phages and eukaryote‐infecting
RNA viruses, are essential components of marine ecosystems. A large number of marine …
RNA viruses, are essential components of marine ecosystems. A large number of marine …
Single-particle studies of the effects of RNA–protein interactions on the self-assembly of RNA virus particles
RF Garmann, AM Goldfain… - Proceedings of the …, 2022 - National Acad Sciences
Understanding the pathways by which simple RNA viruses self-assemble from their coat
proteins and RNA is of practical and fundamental interest. Although RNA–protein …
proteins and RNA is of practical and fundamental interest. Although RNA–protein …
Structural Basis for Alternative Self-Assembly Pathways Leading to Different Human Immunodeficiency Virus Capsid-Like Nanoparticles
J Escrig, íñigo Marcos-Alcalde, S Domínguez-Zotes… - ACS …, 2024 - ACS Publications
The mechanisms that underlie the spontaneous and faithful assembly of virus particles are
guiding the design of self-assembling protein-based nanostructures for biomedical or …
guiding the design of self-assembling protein-based nanostructures for biomedical or …
Close packings of identical proteins in small spherical capsids and similar proteinaceous shells
SB Rochal, OV Konevtsova, IY Golushko, R Podgornik - Soft Matter, 2023 - pubs.rsc.org
Understanding the principles governing protein arrangement in viral capsids and structurally
similar protein shells can enable the development of new antiviral strategies and the design …
similar protein shells can enable the development of new antiviral strategies and the design …
An interaction network approach predicts protein cage architectures in bionanotechnology
F Fatehi, R Twarock - … of the National Academy of Sciences, 2023 - National Acad Sciences
Protein nanoparticles play pivotal roles in many areas of bionanotechnology, including drug
delivery, vaccination, and diagnostics. These technologies require control over the distinct …
delivery, vaccination, and diagnostics. These technologies require control over the distinct …