Many genomic analyses start by aligning sequencing reads to a linear reference genome.
However, linear reference genomes are imperfect, lacking millions of bases of unknown …

Although infectious diseases impose a heavy economic burden on the cattle industry, the
etiology of many disorders that affect livestock is not fully elucidated, and effective …

Bees are associated with a remarkable diversity of microorganisms, including unicellular
parasites, bacteria, fungi, and viruses. The application of next-generation sequencing …

Genomic imprinting is an epigenetic mechanism that leads to parental-allele-specific gene
expression. Approximately 150 imprinted genes have been identified in humans and mice …

Infertility and subfertility represent major problems in domestic animals and humans, and the
majority of embryonic loss occurs during the first month of gestation that involves pregnancy …

Background A widely used approach in next-generation sequencing projects is the
alignment of reads to a reference genome. Despite methodological and hardware …

Genetic data generated by high-throughput sequencing and deposited in public databases
are increasing exponentially. A substantial amount of these data is generated from wild …

Whole genome sequencing (WGS) datasets, usually generated for the investigation of the
individual animal genome, can be used for additional mining of the fraction of sequencing …

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a
context-dependent and tissue-specific manner. In contrast to human, where comprehensive …

Background Decreasing sequencing costs and development of new protocols for
characterizing global methylation, gene expression patterns and regulatory regions have …