X-linked hypophosphataemia (XLH) is the most frequent cause of hypophosphataemia-
associated rickets of genetic origin and is associated with high levels of the phosphaturic …

Abstract Fibroblast growth factor 23 (FGF23) was initially characterized as an important
regulator of phosphate and calcium homeostasis. New research advances demonstrate that …

Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

Rickets is a bone disease associated with abnormal serum calcium and phosphate levels.
The clinical presentation is heterogeneous and depends on the age of onset and …

In children, hypophosphatemic rickets (HR) is revealed by delayed walking, waddling gait,
leg bowing, enlarged cartilages, bone pain, craniostenosis, spontaneous dental abscesses …

The family with sequence similarity 20, member C (Fam20C) has recently been identified as
the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs …

Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also
an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in …

In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …

Phosphate plays many essential roles in our body. To accomplish these functions, serum
phosphate needs to be maintained in a certain range. Serum phosphate level is regulated …

Phosphate plays essential roles in many biological processes, and the serum phosphate
level is tightly controlled. Chronic hypophosphatemia causes impaired mineralization of the …